The antiulcer and autonomic pharmacology of pyridyl-2-thioacetamide (CMN 131).

Abstract

Pyridyl-2-thioacetamide-CMN 131-possess high ulcer-protective activity which seems closely related to its gastric antisecretory properties previously described. This activity is demonstrated using experimental models whose ulcerogenic stimulus can be related to various origins: 4-hr and 24-hr restraint stress ulcers and aspirin or phenylbutazone gastric erosions in rats, histamine-induced ulcers in guinea pigs, reserpine-induced ulcers in cats. In the same dose range used in the ulcer study, and even at higher doses, CMN 131 fails to show any systemic activity on the cholinergic or adrenergic pathway. At a systemic level no antihistaminic, antiserotonin, or ganglion properties can be observed either. Furthermore, CMN 131 modifies neither the salivary and lacrymal secretions, nor the gastric emptying or the blood pressure. Finally, CMN 131 can be considered an original pharmacological agent whose wide antiulcer and antisecretory properties could enable us to understand more clearly the intrinsic mechanism of gastric secretion.