Abstract
Long-term control of cancer depends on synergistic combinations of local and systemic therapy. Radiation is known to have synergistic and additive effects with a number of agents, although its effects on normal tissue are sometimes amplified. The inhibition of angiogenesis should enhance the control of primary tumors, aid in radiation control, and impair the ability of disseminated tumor cells to produce metastases. Thus, we studied the antitumor effect of MRx102 (a synthetic derivative of triptolide isolated from Tripterygium wilfordii).
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