Abstract
Development and Validation of a New Simple Liquid Chromatographic Method for Determination of Coumarin and its 7-Hydroxy Metabolite as a Marker of Cytochrome P450 2A6 in RatsSundeep Bath, Wael Ebied, Hytham Ahmed, Fawzy Elbarbry
Highlights
Cancer is the second leading cause of death worldwide (Klaunig et al, 2011; Lima et al, 2016)
Our results revealed antitumor effect for Sul via, at least in part, induction of apoptosis and reduction of oxidative stress
Our results showed a significant increase in plectin expression in Ehrlich solid tumor tissues and a notable reduction following treatment by Sul
Summary
Cancer is the second leading cause of death worldwide (Klaunig et al, 2011; Lima et al, 2016). Cruciferous vegetables are one such family containing chemo-protective substances. Previous studies suggest that intake of cruciferous vegetable reduces overall cancer risk, especially during the early stages and increasing its intake provides protection at all stages of carcinogenesis (Clarke et al, 2008; Joseph et al, 2004). Cabbage (Brassica oleracea) is one of the cruciferous vegetable families (Rokayya et al, 2013). Many research studies have focused on the beneficial effects of cabbage phytochemicals, especially its indole-3-carbinole (I3C), sulforaphane (Sul), and indoles (Brooks et al, 2001). Cabbage content of Sulforaphane (Sul) ranged around 7.58 μg/g DW and its ideal dose is 0.1–0.5 mg/kg in mice (Campas-Baypoli et al, 2009). Sul can act via several mechanisms that suppress cancer progression
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
