Abstract
Breast cancer (BCa) is the leading cause of women's death worldwide; among them, triple-negative breast cancer (TNBC) is one of the most troublesome subtypes with easy recurrence and great aggressive properties. Spatholobus suberectus Dunn has been used in the clinic of Chinese society for hundreds of years. Shreds of evidence showed that Spatholobus suberectus Dunn has a favorable outcome in the management of cancer. However, the anti-TNBC efficacy of Spatholobus suberectus Dunn percolation extract (SSP) and its underlying mechanisms have not been fully elucidated. Hence, the present study is aimed at evaluating the anti-TNBC potential of SSP both in vitro and in vivo, through the cell viability, morphological analysis of MDA-MB-231, LDH release assay, ROS assay, and the tests of GSH aborted pyroptotic noninflammasome signaling pathway. Survival analysis using the KM Plotter and TNM plot database exhibited the inhibition of transcription levels of caspase-4 and 9 related to low relapse-free survival in patients with BCa. Based on the findings, SSP possesses anti-TNBC efficacy that relies on ROS-induced noncanonical inflammasome pyroptosis in cancer cells. In this study, our preclinical evidence is complementary to the preceding clinic of Chinese society; studies on the active principles of SPP remain underway in our laboratory.
Highlights
There are seldom chemotherapeutic medications that can gain moderate success in triple-negative breast cancer (TNBC) management
TNBC accounts for almost 10-15% of all BCs, which refers to the absence of estrogen and progesterone receptors and overexpression of human epidermal growth receptor 2 [1, 2]
SSD has been used in the clinic of traditional Chinese medicine (TCM) as a potential drug to treat Breast cancer (BCa) patients and accounts for excellent response [19]
Summary
There are seldom chemotherapeutic medications that can gain moderate success in triple-negative breast cancer (TNBC) management. TNBC accounts for almost 10-15% of all BCs, which refers to the absence of estrogen and progesterone receptors and overexpression of human epidermal growth receptor 2 [1, 2]. It is one of the most troublesome subtypes of BCa because of its easy recurrence and highly aggressive properties. Some basic investigations related to immunotherapy and targeted therapy have shown great potential to inhibit the development of cancer [3, 4], they still seldom chemotherapeutic drugs, which can offer positive pathologic complete response for the management of TNBC in the clinic [5].
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