Abstract
Summary The results of approximately six hundred titrations of sera from 244 children, given three injections of “unmodified” diphtheric toxoid, are presented by showing the per cent distribution of children, by antitoxin levels, at certain intervals of time after the last injection. The tabulated results are suggested as a standard of measurement or yard-stick for assessing the relative value of any given diphtheric antigen. The antitoxin levels three months after three injections of unmodified toxoid compare favorably with the levels of antitoxin in a group of “naturally” immune persons. These results were obtained during a time when the incidence of diphtheria infection was low, as evidenced by the morbidity rates, by carrier studies and by the fact that, among the sera serially titrated, in five instances only was there an indication of a rise in antitoxin level due to secondary stimulus. A graph showing the rate of loss of antitoxin of the group as a whole is presented. The antitoxic responses to various diphtheric antigens are presented and compared with the suggested standard.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
