The antiphospholipid syndrome may induce non-thrombotic internal jugular vein stenosis: two cases report

Si-Ying Song,Yu-Chuan Ding,Gary Rajah,Ran Meng,Xun-Ming Ji

doi:10.1186/s12883-020-02035-1

Abstract

BackgroundAntiphospholipid syndrome (APS) is associated with a high incidence of thrombotic events, either arterial thrombosis or venous thrombosis. However, APS-related non-thrombotic venous stenosis is rarely reported.Case presentationThis study described two cases of young women with APS-related internal jugular vein stenosis (IJVS) and reviewed current literature on this issue, including clinical features, diagnosis, and treatment.ConclusionsIJVS is a rather rare complication of APS. Two cases were reported for the first time that high titer of antiphospholipid antibodies (aPL) might mediate direct vessel wall damage and further induce venous stenosis despite long-term standardized anticoagulation to prevent thrombus formation. Therefore, dynamic monitoring of autoantibodies and concomitant use of anticoagulants and corticosteroids may be necessary to the management of APS and its complications.

Highlights

Antiphospholipid syndrome (APS) is associated with a high incidence of thrombotic events, either arterial thrombosis or venous thrombosis
Our previous work firstly classified internal jugular vein stenosis (IJVS) based on its etiology, including thrombotic IJVS and non-thrombotic IJVS [4]
It is well known that venous thrombosis is the most common

Summary

Introduction

Antiphospholipid syndrome (APS) is associated with a high incidence of thrombotic events, either arterial thrombosis or venous thrombosis. * Correspondence: victor65@126.com 1Department of Neurology, Xuanwu Hospital, Capital Medical University, Chang Chun road 45, Xicheng, Beijing, China 2Advanced Center of Stroke, Beijing Institute for Brain Disorders, Beijing 100053, China Full list of author information is available at the end of the article ambiguous classification of APS thrombotic complications when patients are combined with other multiple vascular risk factors in clinical settings. We reported two young female patients of APS with nonthrombotic internal jugular vein stenosis (IJVS) presenting with intracranial hypertension symptoms even after long-term standardized anticoagulation and corticosteroids.

Results

Conclusion