The Anti-Perosis Complex.

Abstract

The role of manganese in preventing perosis in chicks was established1 some time ago, and more recently it was demonstrated by Hogan, Richardson, and Patrick2 that an organic factor is equally essential. Both are required to prevent the disease. This organic nutrient is present in a 95% alcohol extract of dried liver but it is absent from the water extract which was prepared after the alcohol extraction. Jukes3 identified choline with the antiperotic agent. Hogan, et al.,4 reported that choline protects chicks against perosis under certain conditions but in their experience it was not the only organic substance required. This report is to describe a type of perosis which results from a deficiency of a third, as yet unidentified, nutrient.Day-old, single-comb White Leghorn chicks were used as experimental animals. The basal ration has the following composition: Casein 35. starch 31. cellulose 3. salt mixture5 4, lard 17, acid hydrolyzed liver residue 10. Each 100 g of the ration was supplemented with 6000 ...