THE ANTIOXIDANT IN THE COMPOSITIONOF ANTIPARASITIC PASTE FOR HORSES

Abstract

The long-running parasitic process adversely affects the viability of the antioxidant defense system, which is reflected in an increase in the onset of the maximum signal reduction and a decrease in the AOA. For the treatment of equine helminth infections, drugs are needed that combine high anthelmintic efficacy with a simultaneous immunostimulating effect. The use of antioxidants in the composition of antiparasitic drugs increases the effectiveness of deworming. The use of the antiparasitic drug alezan containing ivermectin, praziquantel and antioxidant santohin in helminthiases of horses once at the rate of 1 g of paste per 100 kg of animal weight in a therapeutic dose ensured the complete elimination of worms from the host's body by the 10th day of research. The drug is used for therapeutic and prophylactic purposes. Significant changes in the content of total protein, alpha- and gamma-globulins, AlAt and AsAt by the 28th day of research indicate that there is no negative effect of deworming. Information was obtained on the positive effect of the antiparasitic paste with antioxidant on the light sum (S) and maximum flare (Imax), which is characterized by a decrease in the level of free radical lipid oxidation with a decrease in the light sum of radicals by 14.6% and an increase in the antioxidant activity of horse serum by 26.5% on the 7th day. By the 14th day, the radical sum of radicals decreased by 16.9%, the maximum luminescence intensity – by 34.3%, and on the 28th day the light sum index was 26.73, which corresponded to the standard data. With chronic parasitic invasion, a low AOA was observed.