Abstract
Isolation of compounds from the root of Rhodiola sachalinensis (RRS) yielded tyrosol (1), salidroside (2), multiflorin B (3), kaempferol-3,4′-di-O-β-D-glucopyranoside (4), afzelin (5), kaempferol (6), rhodionin (7), and rhodiosin (8). Quantification of these compounds was performed by high-performance liquid chromatography (HPLC). To investigate the antioxidant and anti-inflammatory effects of the compounds, DPPH radical scavenging, NBT superoxide scavenging and nitric oxide production inhibitory activities were examined in LPS-stimulated Raw 264.7 cells. We suggest that the major active components of RRS are herbacetin glycosides, exhibiting antioxidant activity, and kaempferol, exhibiting anti-inflammatory activity.
Highlights
IntoductionBOR belongs to the family Crassulaceae, and the root of the plant (RRS)
Han Hyuk Kim, Su Hyun Cho, Eun Kyung Chung, Sung Yi Ha and Min Won Lee *
Repeated column chromatography was performed for each fraction to yield tyrosol (1) [11], salidroside (2) [12], multiflorin B (3) [13], kaempferol-3,4′-di-O-β-D-glucopyranoside (4) [14], afzelin (5) [15], kaempferol
Summary
BOR belongs to the family Crassulaceae, and the root of the plant (RRS). RRS has been used to treat flu-like symptoms and fatigue and is known to prevent high altitude sickness [1,2,3]. It has been reported that extracts of RRS and compounds isolated from RRS possess antioxidant [4], anti-inflammatory [5], hepatoprotective [6], sedative, hypnotic [7] and anti-fatigue effects [8]. Various phenolic compounds are found in RRS, such as phenyl propanoids [9], flavonoids and gallic acid. We describe the isolation, analysis, and quantification of the phenolic compounds in RRS, followed by an evaluation of the antioxidant and anti-inflammatory activities of these compounds
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