Abstract
New data on the role of the antioxidant system in the mechanisms of the pathogenesis of chronic obstructive pulmonary disease (COPD) and in combination with coronary heart disease (CHD) have been studied. An effective micromethod for the assessment of total antioxidant activity in human blood plasma has been defined. The ambiguous nature of the oxidant/antioxidant system changes in COPD as well as effects of tobacco smoke have been outlined. It has been shown that at the cardiorespiratory pathology aggravation, the free radical oxidation reactions enhance, but with aging, the nonspecific changes are observed. Information on the effectiveness of various antioxidant drugs in the treatment of COPD and in combination with CHD is given. Prospects for the development of research in the individual selection of medications are outlined.
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