The Antinociceptive Effects of Pregabalin on Post-Operative Hysterectomy Patient

Abstract

Postoperative pain experienced by patients who completed surgery should receive serious attention, because of effective postoperative pain management will reduce morbidity and mortality, accelerate the mobilization and reducing hospitalization time of patients. These studies aim to determine the effect of pregabalin on antinociception and substan-glutamate levels in the blood of patients with postoperative P hysterectomy. This research is an experimental study, namely the Controlled Trial Randomized clinical trials in which patients were randomly divided into two groups by the number of patients who be included 52 people (aged 20-50 years) who underwent hysterectomy surgery. They were divided into group I (n=26) orally administered pregabalin 3 mg/kg body weight and group II (n=26) placebo given orally, 1 hour before surgery. All patients are given general anesthesia that premedication with atropine sulfate and fentanyl injection, induction with propofol and atracurium injection, intubation and breath control, and maintenance of anesthesia with N2O:O2 and isoflurane. The total of postoperative use of morphine injection is assessed until 24 hours postoperative. Examination of the levels of glutamate and substan-P performed preoperative blood before administration and 1 hour postoperative pregabalin. The results showed a marked increase in the level of pain (VAS), blood pressure, heart rate and the amount of postoperative morphine consumption in patients who were given the placebo group, compared with patients given pregabalin group. It was concluded that preoperative pregabalin administration can suppress the increase in glutamate production and can reduce postoperative production of substan-P, and the subsequent decline in glutamate levels in the blood substan-P will provide antinociception effect is a decrease in the level of postoperative pain experienced by patients.