The anti-inflammatory effects of aerobic exercise in asthma is mediated by purinergic signaling

Abstract

Asthma is a chronic allergic airway inflammatory disease. Purinergic signaling, especially through the accumulation of extracellular adenosine triphosphate (ATP) activating P2X7 receptor (P2X7r) has a key role in asthma. Aerobic physical training (APT) improves allergic airway inflammation, but the role of purinergic signaling in its effects are unknown. Thus, 40 C57Bl/6 mice were distributed in Control, APT, HDM (dermatophagoides pteronyssinus), and HDM+APT groups. Treadmill APT was performed 5x/week, during 4 weeks after chronic allergic airway inflammation. APT in asthma groups reduced the accumulation of extracellular ATP in BAL (p