Abstract
The component composition and antihypoxic activity of Siberian fir (Abies sibirica) essential oil fractions were researched. The foliage of Siberian fir, collected on the territory of the Ilyinsky district of the Perm region in a dark coniferous forest was the raw material for obtaining the essential oil. Samples for the research were collected in December 2018 from trees 40–50 years old. The essential oil was obtained with the Clevenger apparatus. Determination of the component composition of Siberian fir essential oil fractions was made by using chromatography-mass-spectrometry. Experiments for determination of antihypoxic activity of Siberian fir essential oil fractions were made on a hypoxic hypoxia model with hypercapnia. According to the results of the research, it was found that the first fraction is more saturated with monoterpene compounds, but the proportion of sesquiterpenoids increases in following fractions. The main components of all fir oil fractions are: bornylacetate, limonene, ∆3-carene, karyophyllene. It was found that the fractions 1 and 2 have the highest antihypoxic activity in comparison with the reference sample. For further research, we offer fraction 1, because it contains the high level of bornylacetate, and the lowest content of ∆3-carene, which inhibits the ubiquinol cytochrome-C reductase complex, interrupting mitochondrial and cell respiration.
Highlights
Пихта сибирская (Abies sibirica) – хвойное вечнозеленое дерево высотой до 30 м с широкопирамидальной кроной
Исследование фракций эфирного масла древесной зелени пихты сибирской является перспективным и требует более детального изучения на других моделях гипоксии с целью определения механизмов действия комплекса активных веществ
Experiments for determination of antihypoxic activity of Siberian fir essential oil fractions were made on a hypoxic hypoxia model with hypercapnia
Summary
Пихта сибирская (Abies sibirica) – хвойное вечнозеленое дерево высотой до 30 м с широкопирамидальной кроной. Антибактериальная активность эфирного масла пихты сибирской в большей степени проявляется на грамположительные микроорганизмы [9]. В литературе имеются сведения о разности компонентного состава фракций эфирного масла пихты сибирской. Представляет интерес выявить фракцию эфирного масла пихты сибирской, которая бы проявляла максимальную биологическую активность.
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