Abstract
Foot-and-mouth disease virus (FMDV)-specified proteins synthesized in infected cells or made in reticulocyte lysates from FMDV RNA have been reacted with hyperimmune or virus particle antiserum and the immune complexes precipitated using protein A bearing Staphylococcus aureus ghosts. Hyperimmune serum precipitates most of the virus-specific proteins efficiently but some of the small polypeptides and P52 and P34, polypeptides derived from the middle of the genome, are precipitated poorly or not at all. Virus particle antiserum precipitates predominantly virus structural proteins and their precursors. Immunoprecipitation of in vitro lysates primed by type A FMDV RNA with type O antisera indicates that some antigenic determinants are shared by polypeptides of the two serotypes. Precipitation of the products of translation of type O virus RNA in vitro shows that the FMDV genome can be translated completely in a reticulocyte lysate and the products efficiently processed.
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