Abstract
Calcium therapy in edemas of irritative and inflammatory origin is known to be capricious. The claims of specific, antiedemic action appear to have more an authoritative than a scientific basis. The specificity is frequently attributed to certain known antipermeability effects of calcium on cells, unicellular organisms and simple membranes in general biology. However, there has not been any satisfactory evidence to corroborate this theoretical possibility in the antiedemic actions. A mere protective action against the formation of edema or effusion is not conclusive evidence of antipermeability. Moreover, it is frequently overlooked that the form of calcium in the body is not comparable with that of the salts used in simple experiments. Besides the antipermeability theory, no satisfactory explanation has been suggested to indicate the probable nature of the antiedemic action of calcium, when this occurs. From the clinical side this is easily understandable, because it is difficult, if not impossible,
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