Abstract
The development of alloxan diabetes in mice is followed by a longer duration of despair behavior, homologous depression in man and a concomitant decrease in the activity of animals in the open field. The 2-week course of α-lipoic acid (α-LA) and reamberin in the doses equivalent to the human therapeutic range exerts an antidepressant activity, as appeared by a reduction in despair behavior and activation of sick mice in the open field. The antidepressant effect of 2-week use of α-LA and reamberin is associated with diminished hyperglycemia. Unlike α-LA, reamberin lowers the blood content of glucose in mice with alloxan diabetes, reduces their mortality, and corrects behavioral disorders in the open field even when relatively low doses are singly administered.
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