Abstract
Cancer is one of the leading causes of deaths worldwide. Compounds derived from traditional Chinese medicines have been an important source of anticancer drugs and adjuvant agents to potentiate the efficacy of chemotherapeutic drugs and improve the side effects of chemotherapy. Herba Epimedii is one of most popular herbs used in China traditionally for the treatment of multiple diseases, including osteoporosis, sexual dysfunction, hypertension and common inflammatory diseases. Studies show Herba Epimedii also possesses anticancer activity. Flavonol glycosides icariin and icariside II are the main bioactive components of Herba Epimedii. They have been found to possess anticancer activities against various human cancer cell lines in vitro and mouse tumor models in vivo via their effects on multiple biological pathways, including cell cycle regulation, apoptosis, angiogenesis, and metastasis, and a variety of signaling pathways including JAK2-STAT3, MAPK-ERK, and PI3k-Akt-mTOR. The review is aimed to provide an overview of the current research results supporting their therapeutic effects and to highlight the molecular targets and action mechanisms.
Highlights
Cancer is a complex genetic disease involving abnormal cell growth and is continue to be one of the major causes of deaths in both developed and developing countries [1]
II can selectively carcinoma,studies prostate have carcinoma, esophageal squamous cell carcinoma, ovarian cancer, kill lungcancer cancer, cells melanoma, leydig cell on tumor, gastric promyelocytic leukemia, sarcoma, without apparent toxicity normal cellsadenocarcinoma, by inducing apoptosis in many cancers, including hepatoblastoma, medulloblastoma, osteosarcoma, epidermoid carcinoma, myeloidovarian leukemia, hepatocellular carcinoma, prostate carcinoma, esophageal squamous cellacute carcinoma, cancer, breast cancer, and multiple myeloma. It seems that icariin and icariside induce apoptosis via both lung cancer, melanoma, leydig cell tumor, gastric adenocarcinoma, promyelocytic leukemia, sarcoma, extrinsic and intrinsic signaling pathways
It was proposed that the inhibitory effect of icariin on the proliferation of vascular smooth muscle cells (VSMCs) might be responsible for the suppression of tumor metastasis
Summary
Cancer is a complex genetic disease involving abnormal cell growth and is continue to be one of the major causes of deaths in both developed and developing countries [1]. Herba Epimedii has been shown to exert anticancer effect on cancer cell lines in vitro and in[16]. Epimedii mouse tumor [17].has been shown to exert anticancer effect on cancer cell lines in vitro and in vivo in mouse tumor model [17]. Icariin was reported to exhibit activity [28,29] and atherosclerosis [30]. Icariin was reported to exhibit anticanceranticancer activity against a againstofahuman series of human series cancer cellcancer lines. Cerebral of bone marrow derived stromal cells [32] It shows protective effects on cognitive deficits [33] and ischemia-reperfusion injury [34]. Icariside II has been demonstrated to possess cytotoxic and cytostatic activities cancer cell lines.
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
