Abstract
Pyridazine nucleus exhibited immense pharmacological activities. Pyridazine nucleus is present in various compounds that possess remarkable pharmacological activities. Various pyridazinone compounds have antitumor activity. Some of them pyridazinone derivatives bearing different moieties were exhibited excellent anticancer activity toward human cancer cell lines. They showed remarkable activity against leukemia, non-small cell lung cancer, colon, central nervous system, melanoma, ovarian and breast cancer cell lines. These compounds were act by different mechanism. Keywords: Pyruvate Kinase; Anti-Cancer; Pyridazines; Biological Activities; Cytotoxicity.
Highlights
IntroductionThe pyridazine compounds are possess almost all types pharmacological activities such as antidepressant, antihypertensive, antithrombotic, anticonvulsant, cardiotonic, antibacterial, diuretic, anti-HIV, hepatoprotective and protaglandin inhibitors (Abdelrazek et al, 2006; Wang et al, 2008; Allerton et al, 2009; Bansal et al, 2009; Costas et al, 2010; Bashir et al, 2010; Zhou et al, 2011; Unsal tan et al, 2011; Faidallah et al, 2011; Husain et al, 2011)
It has been reported that pyridazinone derivative have remarkable anticancer activity
The present review focuses on pyridazines and related compounds which possess potential anticancer activities (Pau et al, 2009; Abd El-Ghaffar et al, 2011)
Summary
The pyridazine compounds are possess almost all types pharmacological activities such as antidepressant, antihypertensive, antithrombotic, anticonvulsant, cardiotonic, antibacterial, diuretic, anti-HIV, hepatoprotective and protaglandin inhibitors (Abdelrazek et al, 2006; Wang et al, 2008; Allerton et al, 2009; Bansal et al, 2009; Costas et al, 2010; Bashir et al, 2010; Zhou et al, 2011; Unsal tan et al, 2011; Faidallah et al, 2011; Husain et al, 2011). It is believed that carbonic anhydrase inhibition, cell cycle arrest in the G1 phase, disruption of microtubule assembly, functional suppression of the transcriptional activator, and angiogenesis (matrix metalloproteinase, MMP) inhibition may be among such relevant mechanisms of these anticancer compounds. Some of these derivatives are currently being evaluated in clinical trials, and there is much optimism that they may lead to novel anticancer drugs, devoid of the side effects of the presently available anticancer drugs (Rathishet al., 2012). As in the case of CDKs, this type of kinase is involved in cancer and neurodegenerative diseases (Knockaert et al 2002; Brana et al 2005)
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