Abstract
Traditional Unani medicine plays a major role in maintaining health in developing countries. For ages, Unani physicians have described many Classical Unani Formulations (CUF) for their anti-cancerous action (Dāfi'-i-saraṭān) in the human population. These formulations contain various individual drugs which also have anticancer activity. The present study was designed to screen and compare cytotoxic and antioxidant properties of different extracts ofAgaricus albusL. (A. albus), a drug used in the Unani system of medicine on human breast cancer cell lines (MCF-7). Cytotoxic effect was assessed using MTT assay kit and free radical scavenging activity was done by using DPPH assay. Aqueous, hydro-ethanol and methanolic extracts were used at different concentrations. All extracts were shown good antioxidant and cytotoxic activity. Among all extracts, maximum cytotoxic effect was observed in methanolic extract and aqueous extract at the concentration of 1,000μg against MCF-7cell line in comparison to paclitaxel. Themaximum antioxidant activity was observed in the hydroethanolic extract at the concentration of 1,000μg against the MCF-7cell line in comparison to ascorbic acid. The present study advocates, the anticancer and antioxidant property of A.albus and suggests that this drug may be used as a potential drug for cancer treatment after a successful and detailed preclinical study and clinical trial.
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