Abstract
Background: Breast cancer chemotherapy with standard drugs such as doxorubicin will induce cardiotoxicity. Therefore, this study aims to evaluate the anticancer activity ofC. odorataleaves extract in DMBA induced breast cancer on rats.Methods: Seven groups ofRattus novergicuswere used: Four treatment groups ofC. odorataextract (500, 1000, 2000, and 4000 mg/kg BW), normal control, breast cancer control, and doxorubicin treatment group. The number, volume, and weight of the nodule and the rats’ body weight were compared among groups. Data was analyzed using paired t-test or one-way ANOVA with post hoc analysis as appropriate.Results: Significant decline of the number, volume, and weight of cancer nodules was observed in the treatment group (p< 0.001). The weight of the cancer nodule at week 16thwas also significantly reduced in GCo2000compared to Gdoxo(p< 0.0001). A significant increase in body weight was also dose-dependent, especially at week 11th(p< 0.05 in all comparisons) and week 16th(p< 0.001 in all comparisons).Conclusion: This study suggested that the ethanol extract ofC. odorataleaves has anticancer and antiproliferative activity.
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