The antibiotic use by pregnant mice was a reason of lung pathology of their offspring

Abstract

The inappropriate antibiotic usage in human and animal treating is a main reason of the antibiotic resistance, spreading wider and wider all over the world. It was proved that the use of antibiotic induces the changes in microbiota profile as well as the protective properties of the intestinal mucosal barrier, determining the level of the bacterial translocation to the distant loci of the body. Pneumonia in newborns is one of the severe pathologies that cause increased neonatal morbidity and mortality. During the newborn period, pneumonia develops much more often than in other age periods. It is considered that main reason of respiratory adaptation disorders and newborns’ pneumonia is the intrauterine infection and the development of the inflammatory process. In animal husbandry we can see that a non- specific bronchopneumonia is one of the main causes of mass mortality of young cattle. There is no any confirmed reason of the growing level of the mortality of cattle. Here we present the results of our investigation which allow suggesting a role of antibiotic use by pregnant females as a basis for the following bacterial translocation to the fetus and a non- specific bronchopneumonia.