Abstract
Partially purified preparations of delta hemolysin demonstrated growth-inhibitory activity against certain Gram-positive bacteria, including certain strains of Staphylococcus aureus. Primary and replica plate assays indicated that the pattern of antibacterial activity manifested against a typical strain, highly sensitive to delta hemolysin, was that given by a typical antibiotic. Bactericidal, bacteriostatic, and stimulation zones were seen, dependent upon the lysin concentration. Certain of the delta hemolysin-producing strains of S. aureus manifested a pattern of growth inhibition wherein particular members of the cultures responded by bacteriostasis to high concentrations of lysin, while the remaining organisms showed no overt growth inhibition. Other strains of delta hemolysin-producing S. aureus were not inhibited in growth by delta hemolysin preparations.The identity of the delta hemolysins and the antibiotic material has not been established. However, analysis by paper chromatography of delta hemolysin preparations revealed at least two hemolytic substances, delta A and delta B, manifesting hemolysis of human erythrocytes and associated with antibiotic activity.
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