Abstract
To evaluate the antibacterial activity of Aspirin, Mefenamic acid and Acetaminophen against Pseudomonas aeruginosa and Staphylococcus epidermidis biofilms. The study was conducted AKU Karachi in collaboration with DIHE Karachi from March 2018 to December 2018.Quantitative spectrophotometric method was used to study the reduction and removal of the Pseudomonas aeruginosa and Staphylococcus epidermidis formed biofilms. Statistical tests were performed using Graph Pad Prism software. . Acetaminophen showed maximum biofilm reduction activity against the biofilms formed by Pseudomonas aeruginosa, and Staphylococcus epidermidis. Mefanamic acid showed maximum biofilm removal potential against Pseudomonas aeruginosa, while Aspirin and Mefanamic acid were equally effective in removing biofilms formed by Staphylococcus epidermidis as well. There is a continuous need to look for non-antibiotic agents for their potential antimicrobial and antibiofilm potential.
Highlights
About 60-80% of all human infections have been found to be associated with biofilm-forming microbes.[1,2] Drug resistance has been frequently attributed to biofilms which are formed by pathogens.[3,4] Staphylococcus (S.) spp. and Pseudomonas (P.) aeruginosa remain significant causes of biofilm-attributed diseases of contact lenses, sutures, ventilation associated pneumonia, mechanical heart valves, vascular grafts, arteriovenous shunts, endovascular catheter infections, and penile and orthopaedic prosthesis.[3]
Such pathogens have been implicated in causing multitude of hospitalacquired infections, namely the emerging Methicillinresistant S. epidermidis (MRSE)[5] and multi-drug resistant P. aeruginosa (MDRPa) infections.[6]
There is constant need to look for non-antibiotic drugs for their potential antimicrobial and antibiofilm potential.[7]
Summary
About 60-80% of all human infections have been found to be associated with biofilm-forming microbes.[1,2] Drug resistance has been frequently attributed to biofilms which are formed by pathogens.[3,4] Staphylococcus (S.) spp. and Pseudomonas (P.) aeruginosa remain significant causes of biofilm-attributed diseases of contact lenses, sutures, ventilation associated pneumonia, mechanical heart valves, vascular grafts, arteriovenous shunts, endovascular catheter infections, and penile and orthopaedic prosthesis.[3] such pathogens have been implicated in causing multitude of hospitalacquired infections, namely the emerging Methicillinresistant S. epidermidis (MRSE)[5] and multi-drug resistant P. aeruginosa (MDRPa) infections.[6] there is constant need to look for non-antibiotic drugs for their potential antimicrobial and antibiofilm potential.[7] Nonsteroidal anti-inflammatory drugs (NSAIDs) are frequently used for relieving pain, inflammation and fever.[8] Some reports have shown the antimicrobial activity of NSAIDS against bacteria.[9,10] The current study was planned to evaluate the antibacterial activity of Aspirin, Mefenamic acid and Acetaminophen against P. aeruginosa and S. epidermidis biofilms
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