Abstract
Excessive use of antibiotics in the livestock and poultry industry has led to antibiotic resistance in livestock and humans. The use of metal Nano-oxides and nanocomposites has been considered as a new strategy to combat infectious diseases. In this study, the antibacterial activity of iron oxide and graphene oxide nanoparticles and their nanocomposites were investigated. aureus; S. For this purpose, antibacterial activity of iron oxide (Fe2o3; F), Graphene oxide (GO), 0.018g reduced graphene oxide-Fe2O3 Nanocomposite (FG1), 0.036g reduced graphene oxide-Fe2O3 Nanocomposite (FG2), 0.072g reduced graphene oxide-Fe2O3 Nanocomposite (FG3) against Gram-negative (Escherichia coli; E. coli) and Gram-positive (Staphylococcus aureus) bacteria was screened. The antibacterial activity of the five different nanoparticles was assessed by minimum inhibitory concentration (MIC), minimum bactericidal concentration (MBC), and the time-kill assay methods. The antibacterial results showed that except for FG1, for the rest of the nanoparticles MIC were 60 μL/mL for E. coli and 50 μL/mL for S. aureus. Moreover, the time-kill assay revealed that the growth of both bacteria was inhibited from the 2nd hour onwards for all nanoparticles. In general, the results of this study showed that iron oxide and graphene oxide nanocomposites increase their antibacterial effect.
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