The Antibacterial Activity of Lavender Essential Oil Alone and In Combination with Octenidine Dihydrochloride against MRSA Strains.

Paweł Kwiatkowski,Emilia Drozłowska,Bartosz Wojciuk,Agata Pruss,Mateusz Kostek,Hanna Zielińska-Bliźniewska,Łukasz Łopusiewicz,Monika Sienkiewicz,Barbara Dołęgowska

doi:10.3390/molecules25010095

Abstract

In the post-antibiotic era the issue of bacterial resistance refers not only to antibiotics themselves but also to common antiseptics like octenidine dihydrochloride (OCT). This appears as an emerging challenge in terms of preventing staphylococcal infections, which are both potentially severe and easy to transfer horizontally. Essential oils have shown synergisms both with antibiotics and antiseptics. Therefore the aim of this study was to investigate the impact of lavender essential oil (LEO) on OCT efficiency towards methicillin-resistant S. aureus strains (MRSA). The LEO analyzed in this study increased the OCT’s susceptibility against MRSA strains. Subsequent FTIR analysis revealed cellular wall modifications in MRSA strain cultured in media supplemented with OCT or LEO/OCT. In conclusion, LEO appears to be a promising candidate for an efficient enhancer of conventional antiseptics.

Highlights

Staphylococcus aureus is a commensal bacterium that can colonize the skin and the mucoses of humans, but is a pathogenic microorganism responsible for many types of infections.The pathogenicity of this bacterium is primarily associated with the variety of virulence factors like enzymes and toxins [1]
There has been a dramatic increase in bacterial resistance to antibiotics and chemotherapeutics, There has been a dramatic increase in bacterial resistance to antibiotics and which limits their therapeutic use
This study showed that a combination of lavender essential oil (LEO) and octenidine dihydrochloride (OCT) increases the effectiveness of this commonly used antiseptic agent against methicillin-resistant S. aureus strains (MRSA) strains

Summary

Introduction

Staphylococcus aureus is a commensal bacterium that can colonize the skin and the mucoses of humans, but is a pathogenic microorganism responsible for many types of infections. The pathogenicity of this bacterium is primarily associated with the variety of virulence factors like enzymes and toxins [1]. Skin and soft tissue infections (SSTIs) are the most common forms of S. aureus etiology [2]. These occur in both outpatients and inpatients.

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