Abstract
The Chaenomeles sinensis fruit is used as an effective antitussive agent, analgesic, and diuretic in traditional Chinese medicine. It has been reported that C. sinensis fruit extracts have antimicrobial and anti-inflammatory effects. However, there are very few reports about the effects of C. sinensis extracts on skin. In this study, we investigated the effect of C. sinensis extracts on skin aging. The results of in vitro assays showed that whole fruit extracts of C. sinensis had superoxide dismutase (SOD)-like activity and inhibited the activity of dermal extracellular matrix proteases: Elastase and collagenase. The inhibitory effect of the whole fruit (containing seeds) extract on elastase activity was higher than that of the sarcocarp (seeds removed) extract. Further, the sarcocarp extract showed a higher level of SOD-like activity and a greater inhibitory effect on collagenase activity than the whole fruit extract. In particular, among the three activities studied, the sarcocarp extract showed the most significant inhibitory effect on collagenase activity at low concentrations. The polyphenol-rich fraction obtained from the sarcocarp showed significant collagenase inhibition. Based on these results, we concluded that phenolic compounds from C. sinensis sarcocarp have the potential to protect against skin aging through anti-collagenase activity.
Highlights
The skin is the largest organ of the human body and plays a major role in protecting the internal organs from the external environment
The sarcocarp extract and fractions were dissolved in distilled water to the appropriate concentration, sarcocarp
The sarcocarp extract and fractions were dissolved in distilled water to the appropriate is describedResults as the are sarcocarp equivalent, calculated the and(nthe collagenase inhibition was determined
Summary
The skin is the largest organ of the human body and plays a major role in protecting the internal organs from the external environment. UV irradiation leads to DNA damage and induces oxidative stress by the production of reactive oxygen species (ROS) [2,3]. These pathways increase the synthesis and activity of proteases that degrade the extracellular matrix (ECM), which comprises collagen and elastin fibers [4]. Takeuchi et al reported that neutrophil elastase activity was increased in mouse skin following UV irradiation [5]. In addition to sunscreen agents, which protect skin from UV-irradiation, by absorbing or reflecting UV light, considerable attention is being paid to supplements that suppression of the formation of ROS and the subsequent activation of ECM-degrading proteases
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