Abstract
Vitamin K is a fundamental enzymatic co-factor implicated in the carboxylation of several vitamin K dependent proteins involved in the pathogenesis of certain age – related diseases. Inflammation is realized as an important factor in such diseases. Vitamin K is recognized to play an anti-inflammatory behavior that is distinct of its action as an enzymatic co- factor by suppressing many signaling pathways mainly the nuclear factor κB (NF-κB) signal transduction pathway. As well as to play a role as an antioxidant versus the generation of reactive oxidative species (ROS). The purpose of this review is to focus on the protective function of vitamin K as an anti-inflammatory agent in these age- associated diseases. And the importance of vitamin K complement as a protective nutrient in aging.
Highlights
Vitamin K is a fundamental enzymatic co-factor implicated in the carboxylation of several vitamin K dependent proteins involved in the pathogenesis of certain age – related diseases
Inflammation can be mediated by the interaction of the inflammatory cytokines with their Toll- like receptors (TLRs) such as tumor necrosis factor-α (TNF-α) receptor, interleukin 1 and 6 (IL-1 and IL6) receptors [10]
Previous studies stated that IL-6 synthesis is under the control of the nuclear factor kappa- B (NF-kB) signaling pathway [23], and that this inflammatory pathway is achieved by interaction with certain receptors that can activate both the STAT and Janus kinase (JAK) signaling pathways [24]
Summary
Vitamin K is a fundamental enzymatic co-factor implicated in the carboxylation of several vitamin K dependent proteins involved in the pathogenesis of certain age – related diseases. Recent studies suggested that vitamin K performs a major part in NF- kB activation pathway, in the regulation of the MAPK signaling pathway [22]. Previous studies stated that IL-6 synthesis is under the control of the NF-kB signaling pathway [23], and that this inflammatory pathway is achieved by interaction with certain receptors that can activate both the STAT and JAK signaling pathways [24].
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