The anti-inflammatory and osteoinductive effect of Simvastatin, possibilities of its use for treatment of periodontal diseases

Abstract

The successful use of surgical and medical methods for the treatment of jawbone restoration has been convincingly confirmed in clinical practice. At the same time, technologies for potentiating the osteoinductive properties of osteoplastic materials to restore bone volume continue to develop. The inclusion of statins in the composition of osteoplastic materials alone or in combination with MSCs is one of the new and promising areas of regenerative action. Objectives — collection and analysis of scientific data on the influence of SMV on the differentiation of MSCs, the participation of SMV in inflammatory processes in periodontal tissues, the search for prospects for the use of SMV as a component of complex therapy of periodontal diseases. Materials and methods. The research of data has been carried out on the databases: PubMed.com, ScienceDirect.com, eLibrary.ru, by the following key words: “simvastatin” AND “periodontitis”, “simvastatin” AND “stromal mesenchymal cells” over the time period from 2014 to 2020; the articles have been selected on the basis of a number of experimental works. Results. The main cellular and genetic ways of implementing the work of SMV in relation to MSCs and periodontal diseases were emphasized, the correlation between the dose-dependent use of SMV with the differentiation of MSCs and the severity of the inflammatory response in periodontal diseases was revealed. Conclusion. SMV is a promising tool for periodontal diseases both at the inflammatory and rehabilitation stages.