Abstract
Extracellular polysaccharide (EPS1-1) was obtained from Rhizopus nigricans and its structural features have been measured. The purpose of this study was to investigate the anti-inflammation effect of EPS1-1 on the chronic atrophic gastritis induced by N-methyl-n'-nitro-n-nitrosoguanidine (MNNG). EPS1-1 could decrease the damage of MNNG including the increased hemorrhagic spots, disorganized glands of gastric mucosa and marked inflammatory cell infiltration. Furthermore, compared to the model group, EPS1-1 treatment could down-regulate the level of inflammation-associated genes and up-regulate the expression of immune-related genes with the analysis of a gene expression profile. Besides, EPS1-1 was found to significantly enhance the immunity of mice. The thymus index of the EPS1-1 group increased significantly compared with that of the model group, and the serum creatinine and blood urea nitrogen levels of kidney and liver decreased in the EPS1-1 group. These studies showed that EPS1-1 may be a beneficial ingredient for improving gastrointestinal health.
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