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Abstract
Angelicae Sinensis Radix (AS), a well-known herb in traditional Chinese medicine (TCM), has been wildly used for replenishing the blood and promoting circulation, in Asia for thousands of years. It has been confirmed that AS also possesses the pharmacological activity of anti-depression. At the same time, recent studies suggested that depression is associated with anemia, and depression could be ameliorated via modulating the blood system. However, it is still unknown whether the anti-depression effect of AS is related to its pharmacological activity of modulating the blood system. In the current study, hematological examination and metabonomic techniques were performed to explore potential anti-depression mechanisms of AS, related to the function of modulating the blood system in a chronic unpredictable mild stress (CUMS) model. The results demonstrated that AS could significantly improve CUMS-induced depressive symptom, hematological anomalies, and hypoxia symptoms. The analysis of metabonomics demonstrated that 26 potential biomarkers in depression could be regulated by the administration of AS. Among them, eight biomarkers participate in the metabolic pathways of amino acid and sphingolipid, and energy metabolism could also be regulated in an anemia model through the administration of AS, as reported in previous literatures. Further results proved that AS modulated energy metabolism in depression through the inhibition of the expression of pyruvate dehydrogenase lipoamide kinase isozyme 1 (PDK-1) and lactate dehydrogenase A (LDHA). These results suggested that the modulation of the blood system was involved in the anti-depression effect of AS. The mechanism may be associated with the promotion of the body’s energy metabolism, the stabilization of cell membranes, the promotion of serum protein synthesis, and the enhancement of immunity.
Highlights
Angelicae Sinensis Radix (AS), known as Danggui in China, has been used widely in Asia for thousands of years because of its pharmaceutical effects on gynecological, cardiovascular and cerebrovascular diseases
On day 0, no significant difference in sucrose preference, body weight or Sucrose Preference Test (SPT) were observed among the five groups
We discovered that anemia accompanied depression, the level of red blood cells (RBC) was increased in the model group and no significant difference was observed in hemoglobin concentration (Hb) between the chronic unpredictable mild stress (CUMS) and control group
Summary
Angelicae Sinensis Radix (AS), known as Danggui in China, has been used widely in Asia for thousands of years because of its pharmaceutical effects on gynecological, cardiovascular and cerebrovascular diseases. Previous reports have demonstrated that AS ethanol extract could attenuate CUMS-induced depressive symptoms by mediating the brain derived neurotrophic factor (BDNF) signaling pathway (Shen et al, 2016). AS water extracts significantly decreased the immobility time of mice in both a tail suspension test (TST) and a forced swimming test (FST) through improving the content of monoamine neurotransmitters and neurotrophic factor in the hippocampus (Liu et al, 2017). This evidence proved that AS possessed an exact antidepressant effect. Despite the discovery of the anti-depression effect of AS, the underlying mechanism has not been investigated yet
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