The anti-chlamydial effect of experimental Mycoplasma pulmonis infection in the murine genital tract.

Abstract

Experimental Chlamydia trachomatis infection of the genital tract of female CBA and TO mice was greatly curtailed by a concurrent genital infection with Mycoplasma pulmonis. TO mice in which chlamydial infection had been suppressed by the mycoplasma infection were treated with the anti-mycoplasma agent, gentamicin. This did not cause a reappearance of the chlamydiae, suggesting that these organisms had been eliminated completely. The M. pulmonis infection stimulated a striking and persistent polymorphonuclear leukocyte response, which may have been the cause of the curtailment of the chlamydial infection.