Abstract
Objective: cataract is the opacity of the lens which progressively impairs the light transmission to the retina and finally prevents the vision, these opacity result from the oxidative process in the eye. The study aimed to prevent opacity of the lens by using Coenzyme Q10 as eye drops.Methods: Sodium selenite 0.01w/v injected intravitreal to the rabbit's eye to induce the disease, a group of rabbits were receive Coenzyme Q10 eye drop, and another group received distilled water, pre and post induction, cataract maturity was measured to evaluate the opacity deterioration.Results: the group of rabbits that received distilled water after induction of cataract, the opacity occurred within 48-72 h and the mean score of opacity reached to (4±0.00), while Coenzyme Q10 treated group the degree of opacity was (1.5±0.02), and there was a highly significant difference (p<0.01).Conclusion: Coenzyme q10 has an antioxidant activity when use as eye drops and this effect enable Coenzyme Q10 to prevent the opacity which is the major cause of cataract due to oxidative stress.
Highlights
Cataract is an illness that affects the eye; it causes opacity of the lens which progressively impairs the light transmission to the retina and prevents the vision
Oxidative damage to lens constituents, including nucleic acids, proteins, and lipids, is considered to be a primary factor in aging-related cataract [1, 2]. Our bodies counteracts this oxidative damage by regular antioxidant defense pathway, with age, activated species of oxygen accumulate while the antioxidant defence system gradually decrease
The type of cataract that was obtained in the present study was Posterior subcapsular (PSC) according to slit-lamp detection and according to opacity classification system, see fig
Summary
Cataract is an illness that affects the eye; it causes opacity of the lens which progressively impairs the light transmission to the retina and prevents the vision. Oxidative damage to lens constituents, including nucleic acids, proteins, and lipids, is considered to be a primary factor in aging-related cataract [1, 2]. Our bodies counteracts this oxidative damage by regular antioxidant defense pathway, with age, activated species of oxygen accumulate while the antioxidant defence system gradually decrease. This accumulation of oxidant products results cross-linking and aggregation of proteins with increasing in molecular weight that can scatter light. Diagnosis of cataract can delays the onset of the disease and reduces the option of surgery by as much as 50% [6]
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