The anti-cancer actions of O6-methylguanine-DNA-methyltransferase in relation to colon polyps

Abstract

BackgroundGenetic variability in DNA repair genes may contribute to differences in DNA repair capacity and susceptibility to colon polyps and cancer. In this study, we examined the role of MGMT polymorphisms in colon polyps formation. MethodsPCR–SSCP analysis was performed included 254 patients with colon polyps and 330 controls. ResultsThe homozygous F84F genotype was significantly more prevalent in study group than in controls. The polymorphic allele 84F was more frequent appeared in group of older patients and in group of smoking patients. On the other hand, there were no association between 84F and gender, size of polyps, cancer family history. ConclusionsWe concluded that high frequency of 84F allele in the group of patients may suggest the role of the MGMT variant in colon polyps etiology.