Abstract
Four new anthraquinone derivatives 1–4 were obtained along with seven known compounds 5–11 from the extracts of the fungal strain Alternaria sp. XZSBG-1 which was isolated from the sediments of the carbonate saline lake in Bange, Tibet, China. Their structures were determined by spectroscopic methods, mainly by 2D NMR spectra. Compound 1 is a novel tetrahydroanthraquinone with an epoxy ether bond between C-4a and C-9a. In the primary bioassays, compound 3 (alterporriol T) exhibited inhibition of a-glucosidase with a IC50 value 7.2 μM, and compound 9 showed good inhibitory activity against the HCT-116 and HeLa cell lines, with IC50 values of 3.03 and 8.09 μM, respectively.
Highlights
In 2002, we reported research on the metabolites of a fungal strain from a saline lake locates in the Bahamas [1]
67.28 ppm), one methoxyl group and one methyl group. These data implied that compound 1 possessed a tetrahydroanthraquinone skeletone (Figure 2)
The sequence data have been submitted to GenBank, accession number HM622756, and the strain was identified as Alternaria sp
Summary
In 2002, we reported research on the metabolites of a fungal strain from a saline lake locates in the Bahamas [1]. It seems that that little research on fungal metabolites from saline lakes has been published. XZSBG-1 collected from the sediment of the salt lake in Bange, Tibet, China was studied. We found that this fungus contained abundant anthraquinone compounds. Four new anthraquinone and tetrahydroanthraquinone derivatives 1–4, were isolated from this fungus along with seven known compounds (5–11) (Figure 1). We report that the isolation, elucidation and biological activities of the anthraquinone and tetrahydroanthraquinone derivatives from Alternaria sp.
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