Abstract
The anthozoan neuropeptide Antho-RWamide I (<Glu-Ser-Leu-Arg-Trp-NH 2) excites contraction of endodermal muscles in sea anemones. Single electrode voltage clamp recordings from semi-intact preparations of endodermal myoepithelial cells reveal that Anthro-RWamide I increases an inward Ca 2+ current. Evidence for the involvement of a Ca 2+ current in contraction was supported by the observation that Cd 2+ abolished spontaneous contractions and reduced inward current. Contractions and inward currents induced by Antho-RWamide I were not, however, completely abolished in the presence of Cd 2+. We conclude that Antho-RWamide, a putative neurotransmitter at sea anemone smooth muscle, acts by opening, either directly or indirectly, Ca 2+ channels in the muscle membrane.
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