Abstract
Abstract This study investigated the effect of anthocyanin extracts from purple-fleshed sweet potato (PSP-AE) on ultraviolet B (UVB)-induced skin photoaging in BALB/c-nu mice. UPLC-QTOF-MS analysis showed six compounds were identified from PSP-AE. Administration of PSP-AE ameliorated the UVB-irradiated macroscopic and histopathological lesions of the skin via suppressing epidermal hyperplasia and collagen degradation, while improving the content of skin moisture and hydroxyproline. Additionally, PSP-AE inhibited the UVB-induced oxidative stress and increased the antioxidant enzyme activities. Results showed PSP-AE inhibited the UVB-irradiated levels of pro-inflammatory cytokines, such as tumor necrosis factor α and interleukin 6. Furthermore, Western blot analysis revealed PSP-AE remarkably decreased the protein levels of phosphorylated c-Jun-Nterminal kinase, extracellular signal-regulated kinase, and p38. Likewise, UVB induced nuclear translocation of nuclear factor kappa-B and the expression of matrix metalloproteinase 1 were diminished by pretreatment of PSP-AE. Therefore, PSP-AE had the potential to attenuate the UVB-irradiated skin oxidative stress and inflammatory response.
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