Abstract
AbstractJervell, J., The antagonistic effect of human plasma albumin on the insulin stimulated of glucose uptake of the isolated rat diaphragm. Acta physiol. scand. 1965, 65, 33–44. — Albumin isolated by several different procedures antagonized the effect of insulin on the glucose uptake of the isolated rat hemidiaphragm. The antagonism was still present after the pH reducing effect of the albumins had been corrected. A decrease in pH was also found to have some insulin‐antagonistic effect. There was no correlation between the antagonistic effect and the free fatty acid content of the albumins, and adding palmitate to a nonantagonistic albumin did not increase its antagonistic activity. The antagonistic effect cannot he explained by the calcium and magnesium binding properties of the albumin.
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