THE ANTAGONISM OF TRPV1 RECEPTORS PREVENT THE CARDIOVASCULAR CHANGES DURING SEPTIC SHOCK

Abstract

IntroductionDuring sepsis there are changes in the cardiovascular system that is characterized by a drop in blood pressure (BP), an increase in heart rate (HR). It has been descript that during the septic shock the endocannabinoid system is active and in high concentrations they could act in vaniloids receptors (TRPV1). Moreover the endocannabinoids, acting in TRPV1 receptors are potent vasodilators, however, your participation has not been fully studied in the septic shock induced by cecal ligation and puncture (CLP).MethodsWistar rats had a radio‐telemetry probe introduced in a descendent aortic to measure cardiovascular activity. At the same time the sepsis was induced by CLP. The TRPV1 antagonist SB366791 in a dose of 2ml/kg was injected intravenous immediately after the end of surgery and the cardiovascular parameters is measured by 8h. Institution's Animal Ethics Committee (N‐082/2010)ResultsThe intravenous treatment with SB366791 a TRPV1 antagonist did not alter the (BP) or (HR), PAM (97±4 vs 96±3 mmHg; t= 0.6, p>;0.05 n=5) and HR (343±4 vs 345±4 bpm; t=0.2; p>;0.05). The treatment with SB366791 was able to decrease the fall in (BP) (F(1,294)= 88, p<0.0001) and the increase in (HR) (F(1,294)=17, p<0,0001) during the septic shock caused by CLP.ConclusionsThe present results indicate that the TRPV1 participate in the genesis of cardiovascular changes during septic shock caused by CLP.