The antagonism of disulphide polypeptides by thiols.

Abstract

British Journal of Pharmacology and ChemotherapyVolume 25, Issue 2 p. 418-431 Free Access THE ANTAGONISM OF DISULPHIDE POLYPEPTIDES BY THIOLS P. J. MARTIN, P. J. MARTIN Department of Pharmacology, University College, LondonSearch for more papers by this authorH. O. SCHILD, H. O. SCHILD Department of Pharmacology, University College, LondonSearch for more papers by this author P. J. MARTIN, P. J. MARTIN Department of Pharmacology, University College, LondonSearch for more papers by this authorH. O. SCHILD, H. O. SCHILD Department of Pharmacology, University College, LondonSearch for more papers by this author First published: October 1965 https://doi.org/10.1111/j.1476-5381.1965.tb02061.xCitations: 5AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL REFERENCES Boyer, P. D. (1958). Sulphydryl and disulphide groups of enzymes. In The Enzymes, vol. 1, p. 511. New York: Academic Press. Dyke, H. B. van, Chow, B. P., Greep, R. O. & Rothen, A. (1942). The isolation of a protein from the pars neuralis of the ox pituitary with constant oxytocic pressor and diuresis-inhibiting activity. J. Pharmacol. exp. Ther., 74, 190– 209. Edman, K. A. P. & Schild, H. O. (1962). The need for calcium in the contractile responses induced by acetylcholine and potassium in the rat uterus. J. Physiol. (Lond.), 161, 424– 441. Eldjarn, L. & Pihl, A. (1957). On the mode of action of x-ray protective agents. II. Interaction between biologically important thiols and disulphides. J. biol. Chem., 225, 499– 510. Evans, D. H. L., Schild, H. O. & Thesleff, S. (1958). Effects of drugs on depolarized plain muscle. J. Physiol. (Lond.), 143, 474– 485. Fastier, F. N. & Smirk, F. H. (1942). The circulatory effects of some iso-thiourea derivatives with special reference to the sensitization of animals to the pressor action of adrenaline. J. Physiol. (Lond.), 101, 379– 388. Foss, O. (1961). Ionic Scission of the Sulfur-Sulfur Bond, vol. 1. Oxford: Pergamon Press. Guttman, S., Jaquenoud, P. A. & Boissonas, H. A. (1957). Ein Nonapeptid mit oxytocin hemmenden Eigenschaften. Naturwissenschaften, 44, 632– 633. Kolthoff, I. M. & Harris, W. K. (1946). Amperometric titration of mercaptans with silver nitrate. Ind. Eng. Chem. Anal. Ed., 18, 161– 169. Martin, P. J. & Schild, H. O. (1962). Effects of thiols on oxytocin and vasopressin receptors. Nature (Lond.), 196, 382– 383. Martin, P. J. & Schild, H. O. (1964). Pharmacological antagonism between SH compounds and S-S polypeptides. Proc. 2nd Int. Pharmacol. Meeting. Prague, 10, 109– 116. Rudinger, J. & Jost, K. (1964). A biologically active analogue of oxytocin not containing a disulfide group. Experientia (Basel), 20, 570– 571. Rudinger, J. & Krejci, I. (1962). Dose-response relations for some synthetic analogues of oxytocin, and the mode of action of oxytocin on the isolated uterus. Experientia (Basel), 18, 585– 588. Sanger, F. (1953). A disulphide interchange reaction. Nature (Lond.), 171, 1025– 1026. Schild, H. O. (1942). A method of conducting a biological assay on a preparation giving repeated graded responses illustrated by the estimation of histamine. J. Physiol. (Lond.), 101, 115– 130. Schwartz, I. L., Rasmussen, H., Schoessler, M. A., Silver, L. & Fong, C. T. O. (1960). Relation of chemical attachment to physiological action of vasopressin. Proc. nat. Acad. Sci. (Wash.), 46, 1288– 1298. Smith, M. W. (1961). Some properties of rat mammary tissue. Nature (Lond.), 190, 541– 542. Citing Literature Volume25, Issue2October 1965Pages 418-431 ReferencesRelatedInformation