The analysis on multi-factors influencing long-term life quality of middle-aged and elderly patients with ischemic stroke

Abstract

Objectives To investigate the factors influencing long-term quality of life(QOL)of patients with first-episode ischemic stroke(IS)and partial side limb dysfunction. Methods 126 cases of the first ischemic stroke patients with partial side limb dysfunction admitted to hospital from November 2012 to July 2013 in Shanghai First People's Hospital were selected.General information of patients was collected and evaluated using NIH Stroke Scale(NIHSS)and Modified Rankin Scale(MRS). Following-up was conducted using NIHSS, MRS, stroke specific quality of life(SS-QOL)and Hamilton Depression Scale(HAMD)during 2-3 years after stroke.Factors related to long-term QOL were screened by single factor analysis, then factors influencing QOL by multiple stepwise regression analysis. Results The average QOL score of patients with first IS partial side limb dysfunction was(181.5 ± 46.4)points scale.In each single scoring, the scale was(10.4±4.3)points in energy, (10.8±4.2)points in family roles, (21.8±6.2)points in language, (22.5±7.6)points in activity, (18.5±6.3)points in mood, (10.1±4.4)in personality, (19.2±5.9)points in self-care ability, (16.1±7.0)points in social roles, (11.65±3.31)points in thinking, (19.1±6.6)points in upper limb function, (14.0±2.0)points in visual acuity, (8.7±4.1)points in work.The multiple regression analysis showed that the influencing factors of life quality included long-term NIHSS evaluation(β=-0.376, P<0.01), HAMD evaluation(β=-0.375, P<0.01), hypertension history(β=-0.178, P<0.05). HAMD evaluation affected 9 fields of QOL, and NIHSS as long-term evaluation affected 6 fields of QOL. Conclusions Predictive factors for declined QOL of first-episode ischemic stroke patients with partial side limb dysfunction include higher NIHSS score, severer depression after long-term stroke and combined hypertension in the early stage.These indicate that recovering of body structure and function injury, control of hypertension, effective prevention and treatment of post-stroke depression maybe important measures for improving life quality of ischemic stroke patients with partial side limb dysfunction. Key words: Stroke; Quality of life; Factor analysis, statistical