The analysis of the entire HLA, partial non‐HLA and HPV for Chinese women with cervical cancer

Abstract

Human leukocyte antigen (HLA) alleles have been associated with an increased or decreased risk of developing cervical cancer through infection with oncogenic forms of the human papillomavirus (HPV). The aim of this study was to analyze the interactions between HPV and HLA, particularly of the entire HLA and partial non-HLA regions, in invasive cervical cancers. The results showed the distribution of HPV genotypes among patients with cervical cancer in this group: the overall prevalence of HPV DNA was 91.3% (274/300). A total of 16 HPV genotypes, HPV16, 18, 58, 33, 81, 31, 68, 39, 67, 6, 11, 26, 52, 62, 66, and 70, were detected in patients with cervical cancer. Among the cervical cancer specimens, 68.7% were positive for HPV16. Genotyping was performed with 112 microsatellite markers spanning the entire HLA region and partial region of chromosome 6q15-16.3. D6S2766 and D6S2764, which are located near to the region containing the HLA-DPB genes, were negatively related with cervical cancer (OR for the D6S2766-195 allele carriers = 0.50), and positively related with cervical cancer (OR for the D6S2764-209 allele carriers = 2.44), respectively. Significant association was found for D6S1043 (allele 132) with HPV16-positive cervical cancer (OR = 4.52). There was an increased risk for carriers of alleles 112 and 132 at the D6S1043 locus, in particular for homozygotes. The present findings indicate that the antigenic presentation of HPV-derived peptides and non-HLA regions may be involved in the pathogenesis of HPV-associated cervical cancer.