The Analysis of Parkinsons Disease using Phase-Amplitude Coupling Method

Abstract

Parkinson's disease (PD) is now the second most prevalent chronic neurological illness worldwide. For motor symptoms of PD, PD is linked to a number of dyskinesia, including rigidity, bradykinesia, postural instability, and tremor at rest. PD dyskinesia is the most common cause of Parkinsonism. Meanwhile, PD dyskinesia may be closely linked to the neural oscillations between neural circuits. PD dyskinesia is associated, in particular, with beta oscillation, which is directly related to the incidence and development of the motor. For the purpose of analysing neural oscillations between neural circuits, phase-amplitude coupling (PAC) can be utilised as a biomarker. As a potential biomarker of beta oscillation, PAC has been widely used in the research of PD. Therefore, this article reviews the latest concepts of dyskinesia, methods of calculating PAC and applications of PAC in Parkinson's disease, aiming to provide a good theoretical basis for finding neural circuits involved in PD dyskinesia to establish better deep brain stimulation therapy.