Abstract
Abstract The physical and chemical properties of methisazone (1-methylindoline-2,3-dione 3-thiosemicarbazone) are described. Iodimetric titration is suggested as being the most convenient method of assay. Each molecule of methisazone reacts with eight atoms of iodine and the mechanism of this reaction is discussed. Methisazone was examined for impurities by thin-layer chromatography and details are given of the technique employed. Reference is made to the change in light absorption of methisazone solutions when exposed to light.
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