Abstract
In their recent paper ‘Analysis of pacemaker activity in the human stomach’, Sanders, Ward and colleagues challenge several fundamental concepts of human gastric slow wave activity Rhee et al. 2011. The authors make the following claims, based on intracellular recordings from isolated gastric tissue strips: (1) The normal human gastric slow wave frequency ranges from approximately 5–8 cycles per minute (cpm), instead of the established 3 cpm; (2) There is no intrinsic interstitial cells of Cajal (ICC) frequency gradient in the human stomach; (3) Slow wave activity occurs in the gastric fundus; (4) The established clinical diagnostic norms for tachygastria and bradygastria are inaccurate; and (5) All past human gastric extracellular recordings are invalidated by movement artifacts.
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