Abstract
This meta-analysis aimed to compare the analgesic efficacy of intraperitoneal ropivacaine versus bupivacaine for laparoscopic cholecystectomy. We searched PubMed, EMbase, Web of Science, EBSCO, and Cochrane Library databases from inception through January 2020 and included randomized controlled trials (RCTs) evaluating the analgesic efficacy of ropivacaine versus bupivacaine for laparoscopic cholecystectomy. Five RCTs are included in the meta-analysis. In patients with laparoscopic cholecystectomy, ropivacaine and bupivacaine demonstrated comparable pain scores at 2h (SMD=-0.22; 95% CI=-0.54 to 0.10; p=0.18), 4h (SMD=-0.16; 95% CI=-0.42 to 0.10; p=0.22), 8h (SMD=-0.60; 95% CI=-1.19 to -0.01; p=0.05), and 24h (SMD=0.33; 95% CI=-1.19 to 1.84; p=0.67), as well as time to first analgesic requirement (SMD=0.10; 95% CI=-0.23 to 0.42; p=0.56). Intraperitoneal ropivacaine and bupivacaine have a similar analgesic efficacy for laparoscopic cholecystectomy.
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