Abstract
Abstract Chlormezanone (2-p-chlorophenyltetrahydro-3-methyl-1,3-thiazin-4-one 1,1-dioxide) given to mice by intraperitoneal injection has an analgesic action of its own, and greatly augments the analgesia produced by morphine-type drugs in this species whether the latter drugs are given by the intraperitoneal or intracisternal route. The analgesic effect of intraperitoneal chlormezanone also adds with and prolongs that of paracetamol in mice, is only weakly antagonised by nalorphine and is moderately augmented by ethanol. Chlormezanone has however no analgesic action when given to mice by the intracisternal route. The implications of this last finding are briefly examined experimentally
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