Abstract
Traumatic brain injury (TBI) can produce cognitive disabilities and death. The most frequent clinical symptoms of TBI are memory loss and unusual behavior or mental health disorders. The present study was aimed to evaluate the effects of chronic oral administration of myricetin (MYR) on behavioral activities (spatial and passive avoidance memory, and motor coordination) and long-term potentiation (LTP) from cornu ammonis area as well as malondialdehyde (MDA) levels in the rat hippocampus following TBI. Brain injury was induced following Marmarou's method. Motor balance, spatial memory test, and passive avoidance task (PAT) were assessed in the Rotarod, Morris water maze, and shuttle-box apparatus, respectively. The level of MDA was measured by ELISA kits and LTP indices were recorded by Electromadule.The results indicated that step-through latency (p < 0.001), LTP indices (p < 0.001) at different times, the percentage of the total time spent by animals in the target quarter (p < 0.001), and the latency times (p < 0.001) were reduced significantly in the TBI rats compared with those of the control group but enhanced significantly in the group treated with MYR compared with those of the TBI group. Motor coordination decreased in the group with TBI (p < 0.001 vs. control). Also, the cerebral MDA concentrations increased following TBI (p < 0.001) and significantly decreased in the group treated with MYR (p < 0.01). MYR improved neurological scores (p < 0.001), memory (p < 0.05, p < 0.01, p < 0.001 at different time points) and LTP indices (p < 0.001) compared with those of the TBI group significantly.The results suggested that MYR could be used as a neuroprotective agent against TBI-induced electrophysiological and behavioral deficits. Several lines of studies are needed to elucidate the possible molecular mechanism of MYR involved in improving cognitive impairments.
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