The ameliorating effect of vitamin D supplementation on metabolic disturbances in polycystic ovary women

Abstract

Our study aims to investigate the impact of Vitamin D supplementation on plasma glucose, lipids and other metabolic and endocrine parameters and evaluate the therapeutic effect of Vitamin D and how to improve insulin levels in patients with Polycystic ovarian syndrome (PCOS). A follow-up research was conducted in Kirkuk from January 5th through June 10th, 2022. There were 80 PCOS women in the research, both married and unmarried, ranging in age from 15 to 45 years old. These patients were hospitalized at Azadi Teaching Hospital's obstetrics and gynecology section. In the present study, 80 PCOS was diagnosed based on the presence of two of the Rotterdam criteria: oligo and anovulation, clinical and biochemical signs of hyperandrogenism, and polycystic ovaries in ultrasound, which were defined as the presence of 12 or more follicles measuring 2-9 mm in diameter in each ovary and ovarian volume more significant than 10 cm3. All 80 PCOS patients were given a comprehensive medical examination, anthropometric measurements, such as weight and height, and a generic questionnaire to fill out. The formula for calculating the Body Mass Index (BMI) was weight (kg)/height2 (m2 ). The mean BMI for PCOS patients was 28.2 (Kg /m²), and the mean for age 30. In our study, insulin level decreased significantly at P value (0.0045 ) with statically no correlation between vitamin D and insulin after three months of vitamin D administration, while insulin resistance level was reduced significantly at P value (< 0.0001) with a negative correlation between vitamin D and insulin resistance, while serum FSB level was raised significantly at P value < (0.0001).ConclusionThe majority of women with PCOS who enrolled in this study were within the childbearing age, and the majority of PCOS women were overweight. Vitamin D was most deficient in PCOS women. In PCOS women, hirsutism, acne, and irregular menstrual cycle were more frequent. Keywords: Polycystic ovarian syndrome; vitamin D; insulin Body Mass Index