The alterations of villous DNA methylation in first trimester associated with the pathogenesis of preeclampsia

Abstract

s / Placenta 35 (2014) A1eA112 A84 compared to control. In a transepithelial transport model, phloretinmediated inhibition of GLUT1 at the apical side of primary cytotrophoblasts showed a 44% of reduction of transepithelial glucose transport at IC50. Conclusions: GLUT1 is down-regulated on protein and functional level in PE compared to control. Altering glucose transport activity by inhibition of apical GLUT-1 indicates that transplacental glucose transport might be regulated on the apical side of the syncytiotrophoblast. These results might help to understand better the regulation of GLUT1 transporter and maybe in future to develop preventive strategies to modulate the fetal programming and thereby reduce the incidence of disease for both the mother and her child later in life. P2.71. THE ALTERATIONS OF VILLOUS DNA METHYLATION IN FIRST TRIMESTER ASSOCIATED WITH THE PATHOGENESIS OF PREECLAMPSIA Keiko Koide, Kyoko Hori, Akihiro Kawashima, Hiroshi Chiba, Ryu Matsuoka, Akihiko Sekizawa Showa University School of Medicine, Tokyo,