THE ALPHA-KETOGLUTARATE DELIVERING SYSTEM FOR CREATINE SUPPLEMENTS IN ELITE ATHLETES

Abstract

363 In this study, the effect of Creatine a-Ketoglutarate (Cr-αKG) was investigated in elite athletes. The procedure of a-KG organic synthesis included production of a bio-heterodimer (BHD), with N-terminals of two molecules of Cr conjugated with both C-terminals of one molecule of α-KG as delivery vehicle. Ten power lifters voluntarily participated in a three months double-blind placebo-controlled (P) experiment. A high intensity free-weight lifting program was adopted. Physical performance, anthropometric, and clinical laboratory blood tests were taken thrice throughout this period. One dose of Cr-αKG equivalent to 4 g· day−1, resulted after one month, compared to (P), in: 1) 10:1 effect by self-evaluating questionnaire; 2) increased squat max., bench-press max., dead-lift max.(p<0.05), number of reps in bench-press and squats with 30% max. weight (p<0.01), upper max.force (p<0.05), stand long jump (p<0.02), decreased time of 70% weight max./10 reps bench-press and squat (20%); 3) increased (weight/height)/body fat index (p<0.05); 4) decreased WBC (3%) and granulocytes (1%), increased RBC (3.5%), Hg (2.8 %), HTC (p<0.05), lymphocytes (p<0.05), and lymphocytes/ granulocytes index (10%). Chemistry blood tests indicated slight glucosemia (6.8 %), less increased cortisol (p<0.05), BUN, Crn, and CO2, and decreased BUN/ Crn (7%), and anion GAP (p<0.05). These data suggest that Cr-αKG as it is formulated in the tested nutrition supplement improves power output physical performance, body composition, and some of characteristic homeostatic indices in elite athletes. Sponsored by Silber SportMed Elite Technologies (SSMET), Inc.